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The rate of recovery of full consciousness among the 42 patients given deferoxamine was 1.3 times that among the 41 given placebo(95 percent confidence interval,0.7 to 2.3);the median time to recovery was 20.2 hours in the deferoxamine group and 43.1 hours in the placebo group(P=0.38). Among 50 patients with deep coma,the rate of recoery of full consciousness was increased 2.2-fold with deferoxamine(95 percent confidence interval,1. 1 to 4.7),decreasing the median recovery time from 68.2 to 24.1 hours(P=0. 03).Among 69 patients for whom data on parasite clearance were available, the rate of clearance with deferoxamine was 2.0 times that with placebo(95 percent confidence interval,1.2 to 3.6).Among all 83 patients,mortality was 17 percent in the deferoxamine group and 22 percent in the placebo group(P=0.52).Iron chelation therapy may hasten the clearance of aprasitemia and enhance recovery from deep coma in cerbral malaria. |
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